Katedra Histologii i Embriologii

ul. Karłowicza 24, 85-092 Bydgoszcz
tel.: +48 52 585 37 25
fax: +48 52 585 37 34
e-mail: kizhistol@cm.umk.pl

Collegium Medicum UMK Collegium Medicum UMK Collegium Medicum UMK

Najważniejsze publikacje

Holtkamp CE, Warmus D, Bonowicz K, Gagat M, Linowiecka K, Wolnicka-Głubisz A, Reiter RJ, Böhm M, Słomiński AT, Steinbrink K, Kleszczyński K. Ultraviolet radiation-induced mitochondrial disturbances are attenuated by metabolites of melatonin in human epidermal keratinocytes. Metabolites 2023 : Vol. 13, nr 7, s. 1-15, 861.

Opacka A, Żuryń A, Krajewski A, Mikołajczyk K. The role of cyclin Y in normal and pathological cells. Cell Cycle 2023 : Vol. 22, nr 8, s. 859-869.

Hałas-Wiśniewska M, Izdebska M, Zielińska W, Kralska J, Zawadka P, Grzanka A. The effect of sanguinarine on the RPMI-7951 and A375 melanoma cell lines. Med. Res. J. 2023 : Vol. 8, nr 1, s. 50-58.

Mlicka A, Mlicki P, Niewiadomski P, Zielińska W, Hałas-Wiśniewska M, Izdebska M. Synergistic effect of metformin and doxorubicin on the metastatic potential of T24 cells.Acta Histochem. 2023 : Vol. 125, nr 1, s. 1-10, 151975.

Piekarska K, Bonowicz K, Grzanka A, Jaworski Ł, Reiter R, Słomiński A, Steinbrink K, Kleszczyński K, Gagat M. Melatonin and TGF-β-mediated release of extracellular vesicles. Metabolites 2023 : Vol. 13, nr 4, s. 1-20, 575.

Möller J.K.S., Linowiecka K., Gagat M, Brożyna A.A., Foksiński Marek, Wolnicka-Głubisz A., Pyza E., Reiter R.J., Tulic M.K., Slominski A.T., Steinbrink K., Kleszczyński K. Melanogenesis is directly affected by metabolites of melatonin in human melanoma cells. Int. J. Mol. Sci. 2023 : Vol. 24, nr 19, s. 1-17, 14947.

Izdebska M, Zielińska W, Krajewski A, Grzanka A. Fascin in migration and metastasis of breast cancer cells: a review. Adv. Med. Sci. 2023 : Vol. 68, nr 2, s. 290-297.

Klimaszewska-Wiśniewska A, Buchholz K, Durślewicz Justyna, Schlee Vilodre E., Gagat M, Grzanka D. SPDL1 is an independent predictor of patient outcome in colorectal cancer. Int. J. Mol. Sci. 2022 : Vol. 23, nr 3, s. 1-17;, 1819.

Durślewicz Justyna, Klimaszewska-Wiśniewska A, Domanowska Ewa, Skoczylas-Makowska Natalia, Antosik P, Zielińska W, Gzil Arkadiusz, Czajkowska P, Mikołajczyk K, Grzanka D. Prognostic significance of SATB1, SMAD3, Ezrin and β-catenin in patients with pancreatic adenocarcinoma. Appl. Sci.-Basel 2022 : Vol. 12, nr 1, s. 1-26, 306.

Bonowicz K, Mikołajczyk K, Faisal Inaz, Qamar Murtaz, Steinbrink K., Kleszczyński K., Grzanka A, Gagat M. Mechanism of extracellular vesicle secretion associated with TGF-β-dependent inflammatory response in the tumor microenvironment. Int. J. Mol. Sci. 2022 : Vol. 23, nr 23, s. 1-12, 15335.

Żuryń A, Krajewski A. Icaritin induces apoptosis and downregulates RhoA/ROCK pathway in the A549 adenocarcinoma cell line. Med. Res. J. 2022 : Vol. 7, nr 3, s. 242-248.

Jaworski Ł, Zabrzyńska M, Klimaszewska-Wiśniewska A, Zielińska W, Grzanka D, Gagat M. Advances in microscopic studies of tendinopathy : literature review and current trends, with special reference to neovascularization process. J. Clin. Med. 2022 : Vol. 11, nr 6, s. 1-10;, 1572.

Zabrzyński J, Gagat M, Huri G., Paczesny Ł, Zielińska W, Zabrzyńska M, Szwedowski D, Kruczyński J. Therapeutic advances in tendinopathy quantified microscopically using Bonar score, with a special reference to PRP therapy : a systematic review of experimental studies. Appl. Sci.-Basel 2021 : Vol. 11, nr 11, s. 1-15;, 4973.

Zielińska W, Zabrzyński J, Gagat M, Grzanka A. The role of TRPM2 in endothelial function and dysfunction. Int. J. Mol. Sci. 2021 : Vol. 22, nr 14, s. 1-11, 7635.

Żuryń A, Opacka A, Krajewski A, Zielińska W, Grzanka A. The less known cyclins : uncovered. Appl. Sci.-Basel 2021 : Vol. 11, nr 5, s. 1-22;, 2320.

Mikołajczyk K, Spyt D, Zielińska W, Żuryń A, Faisal I, Qamar M, Świniarski P, Grzanka A, Gagat M. The important role of endothelium and extracellular vesicles in the cellular mechanism of aortic aneurysm formation. Int. J. Mol. Sci. 2021 : Vol. 22, nr 23, s. 1-15;, 13157.

Zabrzyński J, Huri G, Gagat M, Łapaj Ł, Yataganbaba A, Szwedowski D, Askin M, Paczesny Ł. The impact of smoking on clinical results following the rotator cuff and biceps tendon complex arthroscopic surgery. J. Clin. Med.2021 : Vol. 10, nr 4, s. 1-12;, 599.

Szwedowski D, Szczepanek J, Paczesny Ł, Zabrzyński J, Gagat M, Mobasheri A, Jeka Sławomir. The effect of platelet-rich plasma on the intra-articular : microenvironment in knee osteoarthritis. Int. J. Mol. Sci. 2021 : Vol. 22, nr 11, s. 1-13;, 5492.

Zabrzyńska M, Grzanka D, Zielińska W, Jaworski Ł, Pękała P, Gagat M. The Bonar score in the histopathological assessment of tendinopathy and its clinical relevance : a systematic review. Medicina-Lithuania 2021 : Vol. 57, nr 4, s. 1-14;, 367.

Gagat M, Zabrzyńska A., Zabrzyńska M, Zielińska W. The advances in diagnostic modalities of disorders of the long head of the biceps tendon : review.Stud. Med. 2021 : T. 37, nr 1, s. 83-90.

Zabrzyński J, Gagat M, Łapaj Ł, Paczesny Ł, Yataganbaba A, Szwedowski D, Huri G. Relationship between long head of the biceps tendon histopathology and long-term functional results in smokers : a time to reevaluate the Bonar score? Ther. Adv. Chronic Dis. 2021 : Vol. 12, s. 1-10.

Klimaszewska-Wiśniewska A, Neska-Długosz I, Buchholz K, Durślewicz J, Grzanka D, Kasperska A, Antosik P, Zabrzyński J, Grzanka A, Gagat M. Prognostic significance of KIF11 and KIF14 expression in pancreatic adenocarcinoma. Cancers 2021 : Vol. 13, nr 12, s. 1-24;, 3017.

Neska-Długosz I, Buchholz K, Durślewicz J, Gagat M, Grzanka D, Tojek K, Klimaszewska-Wiśniewska A. Prognostic impact and functional annotations of KIF11 and KIF14 expression in patients with colorectal cancer. Int. J. Mol. Sci. 2021 : Vol. 22, nr 18, s. 1-21;, 9732.

Szwedowski D, Jaworski Ł, Szwedowska W, Pękala P, Gagat M. Neovascularization in meniscus and tendon pathology as a potential mechanism in regenerative therapies : special reference to platelet-rich plasma treatment. Appl. Sci.-Basel 2021 : Vol. 11, nr 18, s. 1-14;, 8310.

Buchholz K, Antosik P, Grzanka D, Gagat M, Smolińska M, Grzanka A, Gzil A, Kasperska A, Klimaszewska-Wiśniewska A. Expression of the body-weight signaling players: GDF15, GFRAL and RET and their clinical relevance in gastric cancer. J. Cancer 2021 : Vol. 12, nr 15, s. 4698-4709.

Klimaszewska-Wiśniewska A, Buchholz K, Neska-Długosz I, Durślewicz J, Grzanka D, Zabrzyński J, Sopońska-Brzoszczyk P, Grzanka A, Gagat M. Expression of genomic instability-related molecules : cyclin F, RRM2 and SPDL1 and their prognostic significance in pancreatic adenocarcinoma. Cancers 2021 : Vol. 13, nr 4, s. 1-19;, 859.

Izdebska M, Zielińska W, Krajewski A, Hałas-Wiśniewska M, Mikołajczyk K, Gagat M, Grzanka A. Downregulation of MMP-9 enhances the anti-migratory effect of cyclophosphamide in MDA-MB-231 and MCF-7 breast cancer cell lines. Int. J. Mol. Sci. 2021 : Vol. 22, nr 23, s. 1-18;, 12783.

Zabrzyński J, Huri G, Yataganbaba A, Paczesny Ł., Szwedowski D, Zabrzyńska A, Łapaj Ł, Gagat M, Wiśniewski M, Pękała P. Current concepts on the morphology of popliteus tendon and its clinical implications. Folia Morphol. 2021 : Vol. 80, nr 3, s. 505-513.

Gagat M, Zielińska W, Mikołajczyk K, Zabrzyński J, Krajewski A, Klimaszewska-Wiśniewska A, Grzanka D, Grzanka A. CRISPR-based activation of endogenous expression of TPM1 inhibits inflammatory response of primary human coronary artery endothelial and smooth muscle cells induced by recombinant human tumor necrosis factor α. Front. Cell Dev. Biol. 2021 : Vol. 9, s. 1-24;, 668032.

Zielińska W, Gagat M, Mikołajczyk K, Hałas-Wiśniewska M, Grzanka A. Low effectiveness of the introduction of pmaxGFP into primary human coronary endothelial cells using cell-penetrating peptides and nuclear-localization sequences in non-covalent interactions. Applied Sciences 2021.

Hałas-Wiśniewska M, Izdebska M, Zielińska W, Grzanka A. Downregulation of FHOD1 Inhibits Metastatic Potential in A549 Cells. Cancer Manag Res. 2021;13:91-106. doi:10.2147/CMAR.S286239

Zabrzynski J, Gagat M, Paczesny L, Grzanka D, Huri G. Correlation between smoking and neovascularization in biceps tendinopathy: a functional preoperative and immunohistochemical study. Ther Adv Chronic Dis. 2020 Oct 7;11:2040622320956418. doi: 10.1177/2040622320956418. 

Hałas-Wiśniewska M, Zielińska W, Izdebska M, Grzanka A. The Synergistic Effect of Piperlongumine and Sanguinarine on the Non-Small Lung Cancer. Molecules. 2020;25(13):3045. doi: 10.3390/molecules25133045.

Żuryń A, Krajewski A, Klimaszewska-Wiśniewska A, Grzanka A, Grzanka D. Expression of cyclin B1, D1 and K in non‑small cell lung cancer H1299 cells following treatment with sulforaphane. Oncol Rep. 2019: 41:1313-1323.

Izdebska M, Zielińska W, Hałas-Wiśniewska M, Mikołajczyk K, Grzanka A. The cytotoxic effect of oxymatrine on basic cellular processes of A549 non-small lung cancer cells. Acta Histochemica 2019;121(6):724-731.

Izdebska M, Zielińska W, Hałas-Wiśniewska M, Grzanka A. Involvement of Actin in Autophagy and Autophagy-Dependent Multidrug Resistance in Cancer. Cancers (Basel) 2019;11(8):1209.

Gagat M, Grzanka D. Letter by Gagat and Grzanka Regarding Article, “Talin-Dependent Integrin Activation Regulates VE-Cadherin Localization and Endothelial Cell Barrier Function”. Circ Res. 2019 Jul 19;125(3):e11-e12. doi: 10.1161/CIRCRESAHA.119.315450.

Izdebska M, Zielińska W, Grzanka D, Gagat M. The Role of Actin Dynamics and Actin-Binding Proteins Expression in Epithelial-to-Mesenchymal Transition and Its Association with Cancer Progression and Evaluation of Possible Therapeutic Targets. Biomedical Research Interntional 2018:4578373.

Izdebska M, Gagat M, Grzanka A. Overexpression of lamin B1 induces mitotic catastrophe in colon cancer LoVo cells and is associated with worse clinical outcomes. Int J Oncol. 2018 J;52(1):89-102.

Gagat M, Zielińska W, Grzanka A. Cell-penetrating peptides and their utility in genome function modifications (Review). International Journal of Molecular Medicine 2017;40(6):1615-1623.

Żuryń A, Litwiniec A, Safiejko-Mroczka B, Klimaszewska-Wiśniewska A, Gagat M, Krajewski A, Gackowska L, Grzanka D. The effect of sulforaphane on the cell cycle, apoptosis and expression of cyclin D1 and p21 in the A549 non-small cell lung cancer cell line. Int J Oncol, 2016; 48: 2521-2533.

Grzanka D, Gagat M, Izdebska M, Marszałek A. Expression of special AT-rich sequence-binding protein 1 is an independent prognostic factor in cutaneous T-cell lymphoma. Oncol Rep. 2015 J;33(1):250-66. doi: 10.3892/or.2014.3597.

Grzanka D, Gagat M, Izdebska M. Involvement of the SATB1/F-actin complex in chromatin reorganization during active cell death. Int J Mol Med. 2014 Jun;33(6):1441-50. doi: 10.3892/ijmm.2014.1710.

Gagat M, Grzanka D, Izdebska M, Sroka WD, Marszałł MP, Grzanka A. Tropomyosin-1 protects endothelial cell-cell junctions against cigarette smoke extract through F-actin stabilization in EA.hy926 cell line. Acta Histochem. 2014 May;116(4):606-18. doi: 10.1016/j.acthis.2013.11.013. 

Żuryń A, Litwiniec A, Klimaszewska-Wiśniewska A, Nowak JM, Gackowska L, Myśliwiec BJ, Pawlik A, Grzanka A. Expression of cyclin D1 after treatment with doxorubicin in the HL-60 cell line. Cell Biol Int, 2014; 38: 857-867.

Żuryń A, Litwiniec A, Gackowska L, Pawlik A, Grzanka AA, Grzanka A. Expression of cyclin A, B1 and D1 after induction of cell arrest in the Jurkat cell line exposed to doxorubicin. Cell Biol Int, 2012;36:1129-1135.

Żuryń A, Grzanka A, Stępień A, Grzanka D, Dębski R, Smoliński D. Expression of cyclin A in human leukemia cell line HL-60 following treatment with doxorubicin and etoposide: the potential involvement of cyclin A in apoptosis. Oncol Rep. 2007; 17: 1013-1019.

Uzyskane Patenty:

Gagat M, Grzanka A, Grzanka D. Stent wewnątrznaczyniowy, zwłaszcza naczyń wieńcowych. Numer prawa wyłącznego: PAT.230281.